The following p-values were obtained for lentiviral A53T-injected monkeys: 2 years vs 8 years, p = 0.080 2 years vs 22 years, p = 0.0068 and 8 years vs 22 years, p = 0.1759. ** p < 0.01, *** p < 0.001 compared with the lentiviral GFP-injected region in 8-year-old monkey. GFAP staining levels were quantified via ImageJ software as the relative intensity over the background. The control substantia nigra regions without lentiviral A53T (noninjected) in the same monkey brain were used as a control.
The data are mean ± SEM from randomly selected images (5–10) per section ( n = 5–8 sections). C, Quantitation of the number of neurons with Lewy neurites per image (400×) (top) and GFAP staining levels (bottom) of the monkey brain tissues injected with lentiviral A53T. Brain sections were stained by an antibody to GFAP. Top and bottom images are from the noninjected and injected substantia nigra, respectively. B, Increased density of reactive astrocytes with age in lentiviral A53T-injected monkey brain regions. Control is the lentiviral-GFP-injected substantia nigra of monkey brain at 8 years of age. Monkey Brains Download 89 KB Monkey Brains Movie For ExampIe Monkey Brains Free Pizza And Plus a Stickér, a Pin évery album in digitaI download format. A, Anti-α-syn staining of the A53T-injected substantia nigra of monkeys at 2, 8, and 22 years of age. Aging promotes the accumulation and neuronal toxicity of A53T in rhesus monkeys.
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